Gisele Picolo Selected Research

Crotoxin

1/2020	The Crotoxin:SBA-15 Complex Down-Regulates the Incidence and Intensity of Experimental Autoimmune Encephalomyelitis Through Peripheral and Central Actions.
11/2019	Crotoxin Conjugated to SBA-15 Nanostructured Mesoporous Silica Induces Long-Last Analgesic Effect in the Neuropathic Pain Model in Mice.
12/2008	The analgesic effect of crotoxin on neuropathic pain is mediated by central muscarinic receptors and 5-lipoxygenase-derived mediators.

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Gisele Picolo Research Topics

Disease

11	Pain (Aches) 12/2022 - 09/2006
11	Hyperalgesia 01/2019 - 05/2003
5	Inflammation (Inflammations) 01/2022 - 07/2009
5	Neuralgia (Stump Neuralgia) 11/2019 - 10/2008
3	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2022 - 12/2017
2	Neuroinflammatory Diseases 12/2022 - 11/2021
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 11/2021 - 01/2020
1	Diabetic Neuropathies (Diabetic Neuropathy) 12/2022
1	Osteoarthritis 12/2022
1	Chronic Pain 01/2022
1	Metabolic Diseases (Metabolic Disease) 12/2021
1	COVID-19 12/2021
1	Obesity 12/2021
1	Demyelinating Diseases (Demyelinating Disease) 09/2020
1	Multiple Sclerosis 01/2020
1	Seizures (Absence Seizure) 01/2020
1	Paralysis (Palsy) 01/2018
1	Arthritis (Polyarthritis) 01/2017
1	Hypersensitivity (Allergy) 11/2016
1	Carcinoma (Carcinomatosis) 08/2013
1	Cancer Pain 08/2013
1	Neuroma 12/2008

Drug/Important Bio-Agent (IBA)

6	crotalphineIBA 11/2021 - 08/2008
6	Analgesics (Analgesic Drugs)IBA 11/2019 - 09/2006
6	VenomsIBA 12/2017 - 05/2003
5	Peptides (Polypeptides)IBA 09/2020 - 10/2008
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2017 - 06/2004
3	CrotoxinIBA 01/2020 - 12/2008
3	Opioid Analgesics (Opioids)IBA 01/2019 - 10/2008
3	ProstaglandinsIBA 08/2008 - 05/2003
3	CarrageenanIBA 08/2008 - 05/2003
2	SBA-15IBA 01/2020 - 11/2019
2	Morphine (MS Contin)FDA LinkGeneric 01/2019 - 10/2008
2	Ion Channels (Ion Channel)IBA 01/2018 - 11/2016
2	Potassium Channels (Potassium Channel)IBA 01/2018 - 05/2003
2	Serotonin ReceptorsIBA 12/2017 - 12/2008
2	Phospholipases (Phospholipase)IBA 12/2017 - 01/2017
2	delta Opioid Receptors (delta Opioid Receptor)IBA 08/2013 - 06/2004
2	Adenosine Triphosphate (ATP)IBA 02/2012 - 05/2003
2	Opioid Receptors (Opioid Receptor)IBA 02/2012 - 10/2008
1	Advanced Glycation End ProductsIBA 12/2022
1	NeuropeptidesIBA 12/2022
1	CollagenIBA 12/2022
1	Substance PIBA 12/2022
1	TubulinIBA 12/2022
1	Biological ProductsIBA 01/2022
1	Hemoglobins (Hemoglobin)IBA 12/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021
1	Bothrops jararaca VenomIBA 01/2021
1	Myelin-Oligodendrocyte GlycoproteinIBA 09/2020
1	hemopressinIBA 01/2020
1	Pilocarpine (Ocusert)FDA LinkGeneric 01/2020
1	Silicon Dioxide (Silica)FDA LinkGeneric 11/2019
1	Carrier Proteins (Binding Protein)IBA 01/2019
1	OligodeoxyribonucleotidesIBA 01/2019
1	Dinoprostone (PGE2)FDA Link 01/2019
1	Mitogen-Activated Protein KinasesIBA 01/2019
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2019
1	Pharmaceutical PreparationsIBA 01/2019
1	ElementsIBA 01/2019
1	SodiumIBA 01/2018
1	crotamineIBA 01/2018
1	Formaldehyde (Formol)FDA Link 12/2017
1	bunodosine 391IBA 12/2017
1	5-HT3 Serotonin Receptors (5 HT3 Receptor)IBA 12/2017
1	KetanserinIBA 12/2017
1	Ondansetron (Zofran)FDA LinkGeneric 12/2017
1	Phospholipids (Phosphatides)FDA LinkGeneric 12/2017
1	Bradykinin B1 ReceptorIBA 01/2017
1	Indomethacin (Indometacin)FDA LinkGeneric 01/2017
1	AntibodiesIBA 01/2017
1	Promethazine (Promet)FDA LinkGeneric 01/2017
1	Celecoxib (Celebrex)FDA Link 01/2017
1	Histamine (Histamine Dihydrochloride)FDA Link 01/2017
1	Serotonin AntagonistsIBA 01/2017
1	ilomastatIBA 01/2017
1	palmitoyl trifluoromethyl ketoneIBA 01/2017
1	arachidonyltrifluoromethaneIBA 01/2017
1	N- (2(R)- 2- (hydroxamidocarbonylmethyl)- 4- methylpentanoyl)- L- tryptophan methylamideIBA 01/2017
1	Metalloproteases (Metalloproteinases)IBA 01/2017
1	Interleukin-6 (Interleukin 6)IBA 01/2017
1	Lipoxygenase InhibitorsIBA 01/2017
1	Cyclooxygenase InhibitorsIBA 01/2017
1	icatibantIBA 01/2017
1	zileuton (Zyflo)FDA Link 01/2017
1	Endothelin Receptors (Endothelin Receptor)IBA 01/2017
1	Bothrops asper myotoxin IIIBA 01/2017
1	Phospholipases A2 (Phospholipase A2)IBA 01/2017
1	Bradykinin B2 ReceptorIBA 01/2017
1	Methysergide (Sansert)FDA Link 01/2017
1	Calcitonin Gene-Related PeptideIBA 11/2016
1	Cyclic GMPIBA 02/2012
1	Arginine (L-Arginine)FDA Link 02/2012
1	Amino Acids FDA Link 02/2012
1	2,5-dichloro-4-bromophenol (B 2)IBA 02/2010

Therapy/Procedure

5	Therapeutics 01/2020 - 09/2006
3	Analgesia 01/2019 - 10/2011
1	Ligation 11/2019
1	Subcutaneous Injections 01/2019
1	Injections 01/2018